RapamycinFungusV1, Main, Exploration, bibRecord, 000D92

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

Identifieur interne : 000D92 ( Main/Exploration ); précédent : 000D91; suivant : 000D93

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

Auteurs : Erwin Swinnen [États-Unis] ; Tobias Wilms ; Jolanta Idkowiak-Baldys ; Bart Smets ; Pepijn De Snijder ; Sabina Accardo ; Ruben Ghillebert ; Karin Thevissen ; Bruno Cammue ; Dirk De Vos ; Jacek Bielawski ; Yusuf A. Hannun ; Joris Winderickx

Source :

Molecular biology of the cell [ 1939-4586 ] ; 2014.

RBID : pubmed:24196832

Descripteurs français

KwdFr :
- Acides gras monoinsaturés (pharmacologie), Antifongiques (pharmacologie), Céramides (biosynthèse), Depsipeptides (pharmacologie), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Régulation de l'expression des gènes fongiques (MeSH), Résistance des champignons aux médicaments (MeSH), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (enzymologie), Sphingolipides (métabolisme), Sphingosine (analogues et dérivés), Sphingosine (pharmacologie), Techniques de knock-out de gènes (MeSH), Tests de sensibilité microbienne (MeSH), Transcription génétique (MeSH), Transport des protéines (MeSH), Type C Phospholipases (métabolisme), Viabilité microbienne (MeSH).
MESH :
- analogues et dérivés : Sphingosine.
- biosynthèse : Céramides.
- effets des médicaments et des substances chimiques : Saccharomyces cerevisiae.
- enzymologie : Saccharomyces cerevisiae.
- génétique : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae.
- métabolisme : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Sphingolipides, Type C Phospholipases.
- pharmacologie : Acides gras monoinsaturés, Antifongiques, Depsipeptides, Sphingosine.
- Régulation de l'expression des gènes fongiques, Résistance des champignons aux médicaments, Techniques de knock-out de gènes, Tests de sensibilité microbienne, Transcription génétique, Transport des protéines, Viabilité microbienne.

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Ceramides (biosynthesis), Depsipeptides (pharmacology), Drug Resistance, Fungal (MeSH), Fatty Acids, Monounsaturated (pharmacology), Gene Expression Regulation, Fungal (MeSH), Gene Knockout Techniques (MeSH), Microbial Sensitivity Tests (MeSH), Microbial Viability (MeSH), Protein Transport (MeSH), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (enzymology), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sphingolipids (metabolism), Sphingosine (analogs & derivatives), Sphingosine (pharmacology), Transcription, Genetic (MeSH), Type C Phospholipases (metabolism).
MESH :
- chemical , analogs & derivatives : Sphingosine.
- chemical , biosynthesis : Ceramides.
- chemical , genetics : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Sphingolipids, Type C Phospholipases.
- chemical , pharmacology : Antifungal Agents, Depsipeptides, Fatty Acids, Monounsaturated, Sphingosine.
- drug effects : Saccharomyces cerevisiae.
- enzymology : Saccharomyces cerevisiae.
- Drug Resistance, Fungal, Gene Expression Regulation, Fungal, Gene Knockout Techniques, Microbial Sensitivity Tests, Microbial Viability, Protein Transport, Transcription, Genetic.

Abstract

The Saccharomyces cerevisiae protein kinase Sch9 is an in vitro and in vivo effector of sphingolipid signaling. This study examines the link between Sch9 and sphingolipid metabolism in S. cerevisiae in vivo based on the observation that the sch9Δ mutant displays altered sensitivity to different inhibitors of sphingolipid metabolism, namely myriocin and aureobasidin A. Sphingolipid profiling indicates that sch9Δ cells have increased levels of long-chain bases and long-chain base-1 phosphates, decreased levels of several species of (phyto)ceramides, and altered ratios of complex sphingolipids. We show that the target of rapamycin complex 1-Sch9 signaling pathway functions to repress the expression of the ceramidase genes YDC1 and YPC1, thereby revealing, for the first time in yeast, a nutrient-dependent transcriptional mechanism involved in the regulation of sphingolipid metabolism. In addition, we establish that Sch9 affects the activity of the inositol phosphosphingolipid phospholipase C, Isc1, which is required for ceramide production by hydrolysis of complex sphingolipids. Given that sphingolipid metabolites play a crucial role in the regulation of stress tolerance and longevity of yeast cells, our data provide a model in which Sch9 regulates the latter phenotypes by acting not only as an effector but also as a regulator of sphingolipid metabolism.

DOI: 10.1091/mbc.E13-06-0340
PubMed: 24196832
PubMed Central: PMC3873890

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Ceramides (biosynthesis)</term>
<term>Depsipeptides (pharmacology)</term>
<term>Drug Resistance, Fungal (MeSH)</term>
<term>Fatty Acids, Monounsaturated (pharmacology)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Gene Knockout Techniques (MeSH)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Microbial Viability (MeSH)</term>
<term>Protein Transport (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Saccharomyces cerevisiae (drug effects)</term>
<term>Saccharomyces cerevisiae (enzymology)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Sphingolipids (metabolism)</term>
<term>Sphingosine (analogs & derivatives)</term>
<term>Sphingosine (pharmacology)</term>
<term>Transcription, Genetic (MeSH)</term>
<term>Type C Phospholipases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras monoinsaturés (pharmacologie)</term>
<term>Antifongiques (pharmacologie)</term>
<term>Céramides (biosynthèse)</term>
<term>Depsipeptides (pharmacologie)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Résistance des champignons aux médicaments (MeSH)</term>
<term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term>
<term>Saccharomyces cerevisiae (enzymologie)</term>
<term>Sphingolipides (métabolisme)</term>
<term>Sphingosine (analogues et dérivés)</term>
<term>Sphingosine (pharmacologie)</term>
<term>Techniques de knock-out de gènes (MeSH)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
<term>Transcription génétique (MeSH)</term>
<term>Transport des protéines (MeSH)</term>
<term>Type C Phospholipases (métabolisme)</term>
<term>Viabilité microbienne (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Sphingosine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Ceramides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Sphingolipids</term>
<term>Type C Phospholipases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term>
<term>Depsipeptides</term>
<term>Fatty Acids, Monounsaturated</term>
<term>Sphingosine</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Sphingosine</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Céramides</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Sphingolipides</term>
<term>Type C Phospholipases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acides gras monoinsaturés</term>
<term>Antifongiques</term>
<term>Depsipeptides</term>
<term>Sphingosine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Resistance, Fungal</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Gene Knockout Techniques</term>
<term>Microbial Sensitivity Tests</term>
<term>Microbial Viability</term>
<term>Protein Transport</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Régulation de l'expression des gènes fongiques</term>
<term>Résistance des champignons aux médicaments</term>
<term>Techniques de knock-out de gènes</term>
<term>Tests de sensibilité microbienne</term>
<term>Transcription génétique</term>
<term>Transport des protéines</term>
<term>Viabilité microbienne</term>
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<front><div type="abstract" xml:lang="en">The Saccharomyces cerevisiae protein kinase Sch9 is an in vitro and in vivo effector of sphingolipid signaling. This study examines the link between Sch9 and sphingolipid metabolism in S. cerevisiae in vivo based on the observation that the sch9Δ mutant displays altered sensitivity to different inhibitors of sphingolipid metabolism, namely myriocin and aureobasidin A. Sphingolipid profiling indicates that sch9Δ cells have increased levels of long-chain bases and long-chain base-1 phosphates, decreased levels of several species of (phyto)ceramides, and altered ratios of complex sphingolipids. We show that the target of rapamycin complex 1-Sch9 signaling pathway functions to repress the expression of the ceramidase genes YDC1 and YPC1, thereby revealing, for the first time in yeast, a nutrient-dependent transcriptional mechanism involved in the regulation of sphingolipid metabolism. In addition, we establish that Sch9 affects the activity of the inositol phosphosphingolipid phospholipase C, Isc1, which is required for ceramide production by hydrolysis of complex sphingolipids. Given that sphingolipid metabolites play a crucial role in the regulation of stress tolerance and longevity of yeast cells, our data provide a model in which Sch9 regulates the latter phenotypes by acting not only as an effector but also as a regulator of sphingolipid metabolism. </div>
</front>
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<DateCompleted><Year>2014</Year>
<Month>08</Month>
<Day>15</Day>
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<Month>11</Month>
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<Title>Molecular biology of the cell</Title>
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<ArticleTitle>The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.</ArticleTitle>
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<Abstract><AbstractText>The Saccharomyces cerevisiae protein kinase Sch9 is an in vitro and in vivo effector of sphingolipid signaling. This study examines the link between Sch9 and sphingolipid metabolism in S. cerevisiae in vivo based on the observation that the sch9Δ mutant displays altered sensitivity to different inhibitors of sphingolipid metabolism, namely myriocin and aureobasidin A. Sphingolipid profiling indicates that sch9Δ cells have increased levels of long-chain bases and long-chain base-1 phosphates, decreased levels of several species of (phyto)ceramides, and altered ratios of complex sphingolipids. We show that the target of rapamycin complex 1-Sch9 signaling pathway functions to repress the expression of the ceramidase genes YDC1 and YPC1, thereby revealing, for the first time in yeast, a nutrient-dependent transcriptional mechanism involved in the regulation of sphingolipid metabolism. In addition, we establish that Sch9 affects the activity of the inositol phosphosphingolipid phospholipase C, Isc1, which is required for ceramide production by hydrolysis of complex sphingolipids. Given that sphingolipid metabolites play a crucial role in the regulation of stress tolerance and longevity of yeast cells, our data provide a model in which Sch9 regulates the latter phenotypes by acting not only as an effector but also as a regulator of sphingolipid metabolism. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Swinnen</LastName>
<ForeName>Erwin</ForeName>
<Initials>E</Initials>
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<Author ValidYN="Y"><LastName>Wilms</LastName>
<ForeName>Tobias</ForeName>
<Initials>T</Initials>
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<Author ValidYN="Y"><LastName>Idkowiak-Baldys</LastName>
<ForeName>Jolanta</ForeName>
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<Author ValidYN="Y"><LastName>Smets</LastName>
<ForeName>Bart</ForeName>
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<Initials>B</Initials>
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	Serveur d'exploration sur la rapamycine et les champignons
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The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.

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